11β-Hydroxysteroid Dehydrogenase Activity in Hypothalamic Obesity
نویسندگان
چکیده
منابع مشابه
The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive cortisone to active cortisol, has been reported to play an important role in metabolic diseases as well as chronic inflammatory diseases. The involvement of 11β-HSD1 in chronic periodontitis was investigated in the present study. The relationship between the levels of 11β-HSD1, chronic periodontitis, and body mass index...
متن کاملAge-related changes in 11β-hydroxysteroid dehydrogenase type 2 activity in normotensive subjects.
BACKGROUND Impairment in 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity results in inefficient inactivation of cortisol to cortisone, and it can trigger hypertension through activation of the mineralocorticoid receptor. Information about age-related changes in 11β-HSD2 activity and its physiological consequences is scarce. Our aim was to investigate whether 11β-HSD2 activity is age...
متن کامل11β-Hydroxysteroid Dehydrogenase-2 and Salt-Sensitive Hypertension.
1335 Glucocorticoid intracellular metabolism, catalyzed by the 2 isozymes of 11β-hydroxysteroid dehydrogenase (11βHSD), determines the corticosteroid action on target tissues. 11β-HSD1 functions as a reductase in most cells and catalyzes the regeneration of active glucocorticoids, thereby amplifying their action. This isozyme is widely expressed in liver, adipose tissue, muscle, pancreatic isle...
متن کامل11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline.
Excess cortisol levels are linked with brain atrophy and cognitive decline in older people. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) potently amplifies intracellular glucocorticoid action by converting inert cortisone to active cortisol, but any causal importance in brain aging is unexplored. We tested the hypotheses that higher systemic 11β-HSD1 activity predicts brain atrophy and co...
متن کامل11β-Hydroxysteroid Dehydrogenase Type 1 and the Metabolic Syndrome
In the past few years, efforts are being made to unravel the mechanisms endowed with the metabolic disturbances associated with obesity that predispose to the metabolic syndrome (MetSyn). The special pathogenic role of liver and visceral adipose tissue (VAT) functions has been particularly intriguing, and many hypotheses have been advanced to explain this association. Tissue-specific actions of...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2003
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2002-020511